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KMID : 0613820180280010083
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Journal of Life Science
2018 Volume.28 No. 1 p.83 ~ p.89
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Effects of Duchesnea chrysantha on Regulation of Antioxidative defense System in Rats Fed a High-fat·High-cholesterol Diet
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Song Won-Young
Choi Jeong-Hwa
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Abstract
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This study was attempted to investigate the effects of Duchesnea chrysantha (DC) on antioxidative activities by in vivo. Rats were divided into four experimental groups which are composed of normal diet group (N group), high fat?high cholesterol diet group (HF group), high fat?high cholesterol diet with 5% DC powder supplemented group (DA group) and high fat?high cholesterol diet with 10% DC powder supplemented group (DB group). Supplementation of DC powder groups resulted in increased activities of hepatic glutathione peroxidase and catalase. The microsomal superoxide radical contents of the DA and DB groups were significantly reduced compared to the high fat?high cholesterol diet group. The mitochondrial superoxide radical contents of the DB group were significantly reduced compared to the high fat?high cholesterol diet group. Hepatic hydrogen peroxide contents in cytosol were significantly reduced 5% and 10% DC powder supplemented group. The carbonyl values contents in mitochondria and microsome of the DA and DB groups were significantly reduced compared to the HF group. Thiobarbituric acid reaction substance (TBARS) values in liver were reduced in 10% DC powder supplemented group compared to the HF group. These results suggest that DC powder may have a strong regulatory effect in the activation of the antioxidative defense system.
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KEYWORD
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Antioxidant system, cholesterol, Duchesnea chrysantha, fat, free radical
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